Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | STAT3 | P40763 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
| ▸ | RXRG | P48443 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26661707 | 0.69 | ALDH1A1 (0.38) | ALDH1A1TSHR | |
| Bicarbonate SCHEMBL15861641 | 0.63 | ALDH1A1 (0.50) | MEN1KMT2ALMNAALDH1A1TSHR | |
| Bicarbonate SCHEMBL7132638 | 0.63 | ALDH1A1 (0.52) | MEN1KMT2APOLBLMNAKDM4E | |
| Acetic Acid SCHEMBL27517007 | 0.61 | ALDH1A1 (0.50) | MEN1KMT2AMAPTLMNAKDM4E | |
| Acetone SCHEMBL11802482 | 0.61 | ALDH1A1 (0.48) | MEN1KMT2AMAPTPOLBLMNA | |
| Toluene SCHEMBL27518969 | 0.61 | AKR1C3 (0.49) | MEN1KMT2APOLBLMNAKDM4E | |
| SCHEMBL30259301 | 0.60 | ALDH1A1 (0.56) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| SCHEMBL31100 | 0.60 | ALDH1A1 (0.56) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| Benzene SCHEMBL28254104 | 0.60 | ALDH1A1 (0.56) | MAPTPOLBLMNAKDM4EALDH1A1 | |
| Acetone SCHEMBL15254621 | 0.60 | ALDH1A1 (0.50) | MEN1KMT2AMAPTPOLBLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | claimed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | claimed |
| EP-2229167-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009078934-A1 | MINERALOCORTICOID RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2009-06-25 | — | — | WO | disclosed |