SCHEMBL3394380

SCHEMBL3394380

COc1ccc(C(C)=O)c(C(F)(F)F)c1

nearest known ligand 0.59

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.59
CYP3A4 P08684 1/20 0.59
HPGD P15428 1/20 0.59
MAPK1 P28482 1/20 0.59
EPHX2 P34913 4/20 0.49
KMT2A Q03164 1/20 0.48
NPC1 O15118 2/20 0.47
RAB9A P51151 1/20 0.47
P2RX1 P51575 1/20 0.46
TMPRSS4 Q9NRS4 1/20 0.46
MAPT P10636 2/20 0.45
LMNA P02545 1/20 0.45
GAA P10253 1/20 0.45
ATM Q13315 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
NPSR1 Q6W5P4 1/20 0.45
TSHR P16473 1/20 0.44
HSD17B10 Q99714 1/20 0.44
KDM4E B2RXH2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1983309 0.88 AKR1C3 (0.53) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL28899309 0.88 NPC1 (0.58) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL22979384 0.85 KDM4E (0.51) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL5460005 0.85 MAPK10 (0.53) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL5729973 0.85 EPHX2 (0.48) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL12251311 0.84 ALDH1A1 (0.61) ALDH1A1CYP3A4HPGDMAPK1KMT2A
SCHEMBL26020311 0.83 EPHX2 (0.47) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL19230564 0.82 MAPT (0.48) ALDH1A1EPHX2KMT2ANPC1RAB9A
SCHEMBL26440433 0.82 LIMK1 (0.49) ALDH1A1CYP3A4HPGDMAPK1EPHX2
SCHEMBL19441829 0.82 KDM4E (0.53) CYP3A4KMT2AMAPTLMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4174069-A1 HETEROCYCLIC COMPOUND AND USE THEREOF Wuhan LL Science and Technology Development Co., Ltd. (CN) 2023-05-03 EP disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
EP-0735142-B1 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICALS CO LTD (JP) 2001-10-24 EP disclosed
US-5717116-A TREATING A MIXTURE OF PHENYLHALOGENOMETHYLCARBINOLS WITH A LIPASE IN THE PRESENCE OF A CARBOXYLATE FOLLOWED BY CYCLIZATION WITH A BASE SUMIKA FINE CHEMICALS COMPANY, LIMITED (JP) 1998-02-10 US disclosed
EP-0735142-A2 Process for producing (R)-styrene oxides SUMIKA FINE CHEMICAL COMPANY, LTD. (JP) 1996-10-02 EP disclosed