Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 5/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395447 | 0.88 | DGAT1 (0.36) | DGAT1BRD4CREBBP | |
| SCHEMBL3395725 | 0.86 | DGAT1 (0.34) | DGAT1BRD4CREBBP | |
| SCHEMBL3398798 | 0.86 | DGAT1 (0.34) | DGAT1 | |
| SCHEMBL3394044 | 0.85 | DGAT1 (0.37) | DGAT1 | |
| SCHEMBL3399612 | 0.84 | DGAT1 (0.34) | DGAT1BRD4CREBBP | |
| SCHEMBL2277340 | 0.84 | DGAT1 (0.36) | DGAT1BRD4CREBBP | |
| SCHEMBL3395608 | 0.80 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL3398477 | 0.79 | DGAT1 (0.32) | DGAT1 | |
| SCHEMBL3393932 | 0.78 | JAK3 (0.36) | — | |
| SCHEMBL3391911 | 0.77 | DGAT1 (0.30) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |