Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 15/20 | 0.61 |
| ▸ | KDR | P35968 | 6/20 | 0.56 |
| ▸ | FLT1 | P17948 | 5/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.55 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.55 |
| ▸ | RAF1 | P04049 | 1/20 | 0.55 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.55 |
| ▸ | TEK | Q02763 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3389209 | 0.93 | EGFR (0.66) | EGFRKDRFLT1ERBB2FLT4 | |
| SCHEMBL3391493 | 0.92 | EGFR (0.72) | EGFRKDRFLT1ERBB2EPHA2 | |
| SCHEMBL3393664 | 0.86 | EGFR (0.59) | EGFRKDRFLT1ERBB2EPHA2 | |
| SCHEMBL3394887 | 0.85 | EGFR (0.69) | EGFRKDRFLT1ERBB2EPHA2 | |
| SCHEMBL3394750 | 0.85 | EGFR (0.85) | EGFRKDRFLT1ERBB2FLT4 | |
| SCHEMBL3391929 | 0.84 | EGFR (0.73) | EGFRKDRFLT1ERBB2EPHB4 | |
| SCHEMBL3391893 | 0.84 | KDR (0.64) | EGFRKDRFLT1ERBB2FLT4 | |
| SCHEMBL3389206 | 0.81 | EGFR (0.89) | EGFRKDRFLT1ERBB2FLT4 | |
| SCHEMBL3395575 | 0.81 | EGFR (0.72) | EGFRKDRFLT1ERBB2EPHA2 | |
| SCHEMBL3390840 | 0.80 | EGFR (0.72) | EGFRKDRFLT1ERBB2EPHA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2167492-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | Hanmi Pharm. Co., Ltd. (KR) | 2010-03-31 | — | — | EP | claimed |
| WO-2008150118-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | HANMI PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | claimed |
| EP-2167492-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | Hanmi Pharm. Co., Ltd. (KR) | 2010-03-31 | — | — | EP | disclosed |
| WO-2008150118-A2 | NOVEL AMIDE DERIVATIVE FOR INHIBITING THE GROWTH OF CANCER CELLS | HANMI PHARM. CO., LTD. (KR) | 2008-12-11 | — | — | WO | disclosed |