Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | CCR6 | P51684 | 1/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 6/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397824 | 0.86 | CCR6 (0.53) | ALDH1A1HPGDCCR6PDE4BPDE4D | |
| SCHEMBL13183043 | 0.84 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL3394598 | 0.82 | ALDH1A1 (0.54) | ALDH1A1HPGDCCR6PDE4BPDE4D | |
| SCHEMBL13183041 | 0.79 | ALDH1A1 (0.53) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL3397845 | 0.72 | SMN1; SMN2 (0.66) | CCR6PDE4BPDE4DMAPTATM | |
| SCHEMBL26740021 | 0.71 | ALDH1A1 (0.51) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL20936275 | 0.70 | ALDH1A1 (0.54) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL22404725 | 0.70 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL21045577 | 0.70 | NPC1 (0.61) | ALDH1A1HPGDMAPTNPC1RAB9A | |
| SCHEMBL20548014 | 0.70 | KDM4E (0.68) | ALDH1A1HPGDMAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | claimed |
| WO-2010098866-A1 | CYCLOPENTATHIOPHENE/CYCLOHEXATHIOPHENE DNA METHYLTRANSFERASE INHIBITORS | SUPERGEN, INC. (US) | 2010-09-02 | — | — | WO | claimed |
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | disclosed |
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | VANKAYALAPATI HARIPRASAD | 2010-09-02 | — | — | US | disclosed |
| WO-2010098866-A1 | CYCLOPENTATHIOPHENE/CYCLOHEXATHIOPHENE DNA METHYLTRANSFERASE INHIBITORS | SUPERGEN, INC. (US) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100222381-A1 | Cyclopentathiophene/cyclohexathiophene DNA methyltransferase inhibitors | DNMT3B, DNMT1, DNMT3L | ALDH1A1 982/4885HPGD 2306/4885CCR6 2654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.