Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LDHA | P00338 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL8962302 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL16568879 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL9247593 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL10903415 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL3815650 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL10901890 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL8862333 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL456119 | 0.95 | — | — | |
| Bicarbonate SCHEMBL8468228 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 | |
| Bicarbonate SCHEMBL15428445 | 0.95 | CA1 (0.56) | CA4CA1CA2CA9FAHD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8889184-B2 | Particulate form of a pharmaceutical composition which is easy to swallow | LOSAN PHARMA GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| EP-2051693-B1 | PHARMACEUTICAL COMPOSITIONS EASY TO SWALLOW, NOT CAUSING ANY UNPLEASANT ORAL SENSATION AND COMPRISING PARTICLES WITH AN ACTIVE PRINCIPLE | LOSAN PHARMA GMBH (DE) | 2010-10-13 | — | — | EP | disclosed |
| EP-2051693-A1 | PHARMACEUTICAL COMPOSITIONS EASY TO SWALLOW, NOT CAUSING ANY UNPLEASANT ORAL SENSATION AND COMPRISING PARTICLES WITH AN ACTIVE PRINCIPLE | Losan Pharma GmbH (DE) | 2009-04-29 | — | — | EP | disclosed |
| US-20080063713-A1 | Outermost coating layer contains neutral methacrylic acid esters copolymer capable of forming a gel with water; sodium glycin carbonate releasing carbon dioxide; adjuvants; promoting salivation with sucrose, glucose, maltodextrin, sorbitol, mannitol, xylitol, maltitol; easily ingestible without water | LOSAN PHARMA GMBH (DE) | 2008-03-13 | — | — | US | disclosed |
| WO-2008019854-A1 | PHARMACEUTICAL COMPOSITIONS EASY TO SWALLOW, NOT CAUSING ANY UNPLEASANT ORAL SENSATION AND COMPRISING PARTICLES WITH AN ACTIVE PRINCIPLE | LOSAN PHARMA GMBH (DE) | 2008-02-21 | — | — | WO | disclosed |