Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL3623405 | 0.95 | CA1 (0.50) | — | |
| Bicarbonate SCHEMBL3395196 | 0.95 | CA4 (0.50) | — | |
| Bicarbonate SCHEMBL2058500 | 0.95 | — | — | |
| Bicarbonate SCHEMBL6898490 | 0.95 | — | — | |
| Bicarbonate SCHEMBL601978 | 0.94 | — | — | |
| Bicarbonate SCHEMBL3369000 | 0.94 | — | — | |
| Bicarbonate SCHEMBL9247678 | 0.89 | CA1 (0.56) | — | |
| Bicarbonate SCHEMBL16568879 | 0.89 | CA1 (0.56) | — | |
| Bicarbonate SCHEMBL8862333 | 0.89 | CA1 (0.56) | — | |
| Bicarbonate SCHEMBL21331688 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5972245-A | USE AS STABILIZER IN A HALOGEN-CONTAINING RESIN COMPOSITION HAVING IMPROVED THERMAL STABILITY, INITIAL COLORING AND IMPROVED COLOR FASTNESS | CHEMSON POLYMER-ADDITIVE GESELLSCHAFT M.B.H. (AT) | 1999-10-26 | — | — | US | claimed |
| EP-3640261-A1 | THERAPEUTIC AGENT FOR CHRONIC ARTHRITIDES DISEASES OF CHILDHOOD-RELATED DISEASES | Chugai Seiyaku Kabushiki Kaisha (JP) | 2020-04-22 | — | — | EP | disclosed |
| US-20180222988-A1 | THERAPEUTIC AGENT FOR CHRONIC ARTHRITIDES DISEASES OF CHILDHOOD-RELATED DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2018-08-09 | — | — | US | disclosed |
| US-20160194401-A1 | THERAPEUTIC AGENT FOR CHRONIC ARTHRITIDES DISEASES OF CHILDHOOD-RELATED DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-07-07 | — | — | US | disclosed |
| US-9255145-B2 | Therapeutic agent for chronic arthritides diseases of childhood-related diseases | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2016-02-09 | — | — | US | disclosed |
| US-8632612-B2 | Compositions for dyeing keratin fibers | SEGETIS, INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-8597644-B2 | Method for treating psoriasis by administering an antibody to interleukin-6 receptor | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-12-03 | — | — | US | disclosed |
| US-8562990-B2 | Method of treating psoriatic arthritis with an IL-6 receptor antibody | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2013-10-22 | — | — | US | disclosed |
| EP-2613760-A2 | COMPOSITIONS FOR DYEING KERATIN FIBERS | Segetis, Inc. (US) | 2013-07-17 | — | — | EP | disclosed |
| US-20130156716-A1 | COMPOSITIONS FOR DYEING KERATIN FIBERS | SEGETIS, INC. (US) | 2013-06-20 | — | — | US | disclosed |
| US-20060182708-A1 | Prebiotically active plant extracts | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2006-08-17 | — | — | US | disclosed |
| US-20040115197-A1 | Remedies for infant chronic arthritis-relating diseases | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-06-17 | — | — | US | disclosed |
| US-20040028681-A1 | Preventives or remedies for psoriasis containing as the active ingredient il-6 antagonist | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-02-12 | — | — | US | disclosed |
| EP-1374900-A1 | REMEDIES FOR INFANT CHRONIC ARTHRITIS-RELATING DISEASES | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-01-02 | — | — | EP | disclosed |
| EP-1334731-A1 | PREVENTIVES OR REMEDIES FOR PSORIASIS CONTAINING AS THE ACTIVE INGREDIENT IL-6 ANTAGONIST | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2003-08-13 | — | — | EP | disclosed |
| US-6333323-B1 | AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS (HIV) DRUGS | SHIONOGI & CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-0672043-A1 | NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1995-09-20 | — | — | EP | disclosed |
| WO-1994001437-A1 | NOVEL 4-(3-BENZOFURANYL)PIPERIDINYL AND 4-(3-BENZOTHIENYL)PIPERIDINYL DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | JANSSEN PHARMACEUTICA N.V. (BE) | 1994-01-20 | — | — | WO | disclosed |
| US-5227276-A | NEGATIVE-WORKING RADIATION-SENSITIVE MIXTURE, AND RADIATION-SENSITIVE RECORDING MATERIAL PRODUCED WITH THIS MIXTURE | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-13 | — | — | US | disclosed |
| EP-0386848-A1 | Novel Exophiala species | GIST-BROCADES N.V. (NL) | 1990-09-12 | — | — | EP | disclosed |