Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPM1B | O75688 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395326 | 1.00 | MAPT (0.44) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL2374740 | 0.91 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL663520 | 0.91 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL663519 | 0.91 | MAPT (0.50) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL21360459 | 0.89 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL1957759 | 0.89 | MAPT (0.51) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL14330028 | 0.89 | MEN1 (0.35) | MAPTMEN1KMT2AALDH1A1GAA | |
| SCHEMBL15308686 | 0.81 | MEN1 (0.44) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL31196261 | 0.81 | MEN1 (0.44) | MAPTMEN1KMT2AALDH1A1CYP3A4 | |
| SCHEMBL19816466 | 0.81 | MEN1 (0.44) | MAPTMEN1KMT2AALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3666758-A1 | PROCESS FOR THE PREPARATION OF A SULFONAMIDE DERIVATIVE | AbbVie Inc. (US) | 2020-06-17 | — | — | EP | disclosed |
| EP-2376480-B1 | SULFONAMIDE DERIVATIVES AS BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBVIE INC (US) | 2016-06-01 | — | — | EP | disclosed |
| WO-2010065865-A2 | BCL-2-SELECTIVE APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE DISEASES | ABBOTT LABORATORIES (US) | 2010-06-10 | — | — | WO | disclosed |