Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | JAK1 | P23458 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | MAP3K11 | Q16584 | 6/20 | 0.41 |
| ▸ | NEK2 | P51955 | 6/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399171 | 0.90 | SYK (0.61) | SYKCYP2C9MAP3K11ADORA3 | |
| SCHEMBL3393945 | 0.86 | SYK (0.59) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3395228 | 0.82 | SYK (0.58) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2277584 | 0.81 | SYK (0.78) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3398014 | 0.81 | MAPK1 (0.46) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396263 | 0.80 | SYK (0.59) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3399252 | 0.80 | SYK (0.58) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL2279926 | 0.79 | SYK (0.76) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL27822514 | 0.79 | SYK (0.69) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3399365 | 0.79 | SYK (0.60) | SYKCYP2C9MAP3K11ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |