Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | MAP3K11 | Q16584 | 7/20 | 0.41 |
| ▸ | NEK2 | P51955 | 4/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 2/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398379 | 0.90 | SYK (0.56) | SYKCYP2C9MAP3K11KIT | |
| SCHEMBL2362208 | 0.85 | SYK (0.54) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396179 | 0.83 | SYK (0.52) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3393945 | 0.82 | SYK (0.59) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3395784 | 0.82 | SYK (0.64) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3398846 | 0.81 | SYK (0.50) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3398152 | 0.81 | SYK (0.50) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396334 | 0.81 | SYK (0.50) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3396263 | 0.80 | SYK (0.59) | SYKCYP2C9JAK2JAK1JAK3 | |
| SCHEMBL3399252 | 0.80 | SYK (0.58) | SYKCYP2C9JAK2JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |