Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.71 |
| ▸ | APP | P05067 | 3/20 | 0.61 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | MTOR | P42345 | 2/20 | 0.56 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 2/20 | 0.56 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 3/20 | 0.54 |
| ▸ | MAOA | P21397 | 2/20 | 0.54 |
| ▸ | NQO2 | P16083 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.52 |
| ▸ | CA1 | P00915 | 2/20 | 0.52 |
| ▸ | CA2 | P00918 | 2/20 | 0.52 |
| ▸ | CA3 | P07451 | 2/20 | 0.52 |
| ▸ | CA4 | P22748 | 2/20 | 0.52 |
| ▸ | CA6 | P23280 | 2/20 | 0.52 |
| ▸ | CA5A | P35218 | 2/20 | 0.52 |
| ▸ | CA7 | P43166 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27557619 | 0.86 | LCK (0.67) | BACE1NPC1HSD17B3MAOBLCK | |
| SCHEMBL699611 | 0.85 | HSD17B3 (0.57) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL699610 | 0.85 | HSD17B3 (0.57) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL8900696 | 0.85 | HSD17B3 (0.57) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL1931278 | 0.85 | APP (0.73) | APPNPC1MTORTTRTRPA1 | |
| SCHEMBL8900441 | 0.85 | HSD17B3 (0.65) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL699462 | 0.85 | HSD17B3 (0.65) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL709614 | 0.85 | HSD17B3 (0.65) | BACE1HSD17B3MAOBMAOAALDH1A1 | |
| SCHEMBL3219281 | 0.84 | BACE1 (1.00) | BACE1HSD17B3MAOBMAOAABCB1 | |
| SCHEMBL3219293 | 0.84 | BACE1 (1.00) | BACE1HSD17B3MAOBMAOAABCB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |