SCHEMBL8900696

SCHEMBL8900696

Brc1ccc(/C=C\c2cccc(Br)c2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B3 P37058 1/20 0.57
ALDH1A1 P00352 2/20 0.56
BACE1 P56817 1/20 0.53
CHRNA7 P36544 1/20 0.49
NFE2L2 Q16236 2/20 0.47
CYP19A1 P11511 2/20 0.47
KDM4E B2RXH2 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45
RAB9A P51151 1/20 0.45
SLC6A19 Q695T7 1/20 0.45
HSD11B1 P28845 1/20 0.44
TUBB4A P04350 1/20 0.44
TUBB P07437 1/20 0.44
TUBA3C P0DPH7 1/20 0.44
TUBA1B P68363 1/20 0.44
TUBA4A P68366 1/20 0.44
TUBB4B P68371 1/20 0.44
TUBB3 Q13509 1/20 0.44
TUBB2A Q13885 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL699610 1.00 HSD17B3 (0.57) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL699611 1.00 HSD17B3 (0.57) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL9971877 0.91 NFE2L2 (0.50) HSD17B3ALDH1A1BACE1NFE2L2CYP19A1
SCHEMBL709614 0.91 HSD17B3 (0.65) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL699462 0.91 HSD17B3 (0.65) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL8900441 0.91 HSD17B3 (0.65) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL699999 0.88 HSD17B3 (0.59) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL699998 0.88 HSD17B3 (0.59) HSD17B3ALDH1A1BACE1CHRNA7NFE2L2
SCHEMBL3395884 0.85 BACE1 (0.71) HSD17B3ALDH1A1BACE1NFE2L2CYP19A1
SCHEMBL11464066 0.81 HSD17B3 (0.61) HSD17B3ALDH1A1BACE1SLC6A19HSD11B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0663391-B1 Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls HOFFMANN LA ROCHE (CH) 1997-04-09 EP disclosed
US-5521160-A COMPOUNDS FOR TREATMENT OF ATHERIOSCLEROSIS IN BLOOD VESSELS AND PREVENTION OF RESTENOSIS AFTER ANGIOPLASTY HOFFMANN-LA ROCHE INC. (US) 1996-05-28 US disclosed
EP-0663391-A1 Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls F. HOFFMANN-LA ROCHE AG (CH) 1995-07-19 EP disclosed