SCHEMBL3395898

SCHEMBL3395898

NCCCN.c1cnc2ncccc2c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 5/20 0.45
HSP90AB1 P08238 4/20 0.45
HRH1 P35367 4/20 0.42
ALDH1A1 P00352 3/20 0.42
KDM4E B2RXH2 3/20 0.41
LMNA P02545 3/20 0.41
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
TP53 P04637 2/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2D6 P10635 2/20 0.41
HIF1A Q16665 2/20 0.41
GMNN O75496 1/20 0.41
MMP2 P08253 1/20 0.41
MAPT P10636 1/20 0.41
MMP9 P14780 1/20 0.41
ALOX15 P16050 1/20 0.41
TSHR P16473 1/20 0.41
NFKB1 P19838 1/20 0.41
MMP8 P22894 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29354893 0.83 CCR1 (0.55) HSP90AA1ALDH1A1KDM4ELMNAMEN1
SCHEMBL8193 0.83 CCR1 (0.55) HSP90AA1ALDH1A1KDM4ELMNAMEN1
SCHEMBL28304525 0.83 CCR1 (0.55) HSP90AA1ALDH1A1KDM4ELMNAMEN1
Hydroxyamine SCHEMBL1686705 0.80 KDM4E (0.52) HSP90AA1HSP90AB1ALDH1A1KDM4ELMNA
Hydrochloric Acid SCHEMBL2284189 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1
Bromide SCHEMBL31044093 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1
SCHEMBL32685215 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1
Ammonia Solution, Strong SCHEMBL2732606 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1
Water SCHEMBL8327751 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1
Hydrochloric Acid SCHEMBL3704753 0.80 CCR1 (0.52) HSP90AA1ALDH1A1KDM4ELMNAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3203840-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR Vertex Pharmaceuticals Incorporated (US) 2017-08-16 EP disclosed
WO-2016057572-A1 MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR MILLER MARK THOMAS (US) 2016-04-14 WO disclosed
EP-2245026-A1 SPIROCYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND METHOD FOR THEIR PRODUCTION Boehringer Ingelheim International GmbH (DE) 2010-11-03 EP disclosed
WO-2009098061-A1 SPIROCYCLIC HETEROCYCLES, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND METHOD FOR THEIR PRODUCTION BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-08-13 WO disclosed