Hydrochloric Acid

Hydrochloric Acid

SCHEMBL2284189

Cl.c1cnc2ncccc2c1

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CCR5 known ✓ P51681 2/20 0.52
HSP90AA1 known ✓ P07900 1/20 0.52
MMP8 known ✓ P22894 1/20 0.52
MMP13 known ✓ P45452 1/20 0.52
CHRM1 known ✓ P11229 1/20 0.42
ADRA1A known ✓ P35348 1/20 0.42
HDAC8 known ✓ Q9BY41 1/20 0.42
CCR1 P32246 4/20 0.52
CCR8 P51685 4/20 0.52
KDM4E B2RXH2 2/20 0.52
LMNA P02545 2/20 0.52
MMP2 P08253 2/20 0.52
TSHR P16473 2/20 0.52
CYP3A4 P08684 2/20 0.52
GMNN O75496 1/20 0.52
TP53 P04637 1/20 0.52
CYP2D6 P10635 1/20 0.52
MAPT P10636 1/20 0.52
MMP9 P14780 1/20 0.52
ALOX15 P16050 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16337846 1.00 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
Hydrochloric Acid SCHEMBL3704753 1.00 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
Hydrochloric Acid SCHEMBL3710471 1.00 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
Hydrochloric Acid SCHEMBL29843308 1.00 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
SCHEMBL8193 0.97 CCR1 (0.55) CCR1CCR8KDM4ELMNAMMP2
SCHEMBL29354893 0.97 CCR1 (0.55) CCR1CCR8KDM4ELMNAMMP2
SCHEMBL28304525 0.97 CCR1 (0.55) CCR1CCR8KDM4ELMNAMMP2
Ammonia Solution, Strong SCHEMBL2732606 0.94 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
SCHEMBL32685215 0.94 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2
Bromide SCHEMBL31044093 0.94 CCR1 (0.52) CCR1CCR8KDM4ELMNAMMP2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 56 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3177619-A1 2-(MORPHOLIN-4-YL)-1,7-NAPHTHYRIDINES Bayer Pharma Aktiengesellschaft (DE) 2017-06-14 EP claimed
CN-106795156-A 2- (morpholin-4-yl) -1, 7-naphthyridine 拜耳制药股份公司 2017-05-31 CN claimed
CN-105884831-A Preparation method of phorate pesticide hapten and application of phorate pesticide hapten 江苏师范大学 2016-08-24 CN claimed
WO-2016020320-A1 2-(MORPHOLIN-4-YL)-L,7-NAPHTHYRIDINES BAYER PHARMA AKTIENGESELLSCHAFT (DE) 2016-02-11 WO claimed
WO-2009111031-A2 METHODS OF TREATING VASOMOTOR SYMPTOMS INTRA-CELLULAR THERAPIES, INC. (US) 2009-09-11 WO claimed
US-5726197-A ADRENORECEPTORS AND ADMINISTERING SYNTEX (U.S.A.) INC. (US) 1998-03-10 US claimed
EP-4720061-A1 TREM2 AGONISTS F. Hoffmann-La Roche AG (CH) 2026-04-08 EP disclosed
WO-2024246018-A1 TREM2 AGONISTS F. HOFFMANN-LA ROCHE AG (CH) 2024-12-05 WO disclosed
CN-118203585-A Pharmaceutical use of ENPP1 inhibitors 上海翊石医药科技有限公司 2024-06-18 CN disclosed
CN-116262750-A Aromatic heterocyclic compound and preparation method and application thereof 上海翊石医药科技有限公司 2023-06-16 CN disclosed
EP-4077306-A1 COMPOUNDS AND PROBES FOR IMAGING HUNTINGTIN PROTEIN CHDI Foundation, Inc. (US) 2022-10-26 EP disclosed
CN-110204544-B 2- (morpholin-4-yl) -1, 7-naphthyridine 拜耳制药股份公司 2022-04-12 CN disclosed
CN-110256427-B 2- (morpholin-4-yl) -1, 7-naphthyridine 拜耳制药股份公司 2022-02-22 CN disclosed
WO-2006135627-A2 INHIBITORS OF AKT ACTIVITY MERCK & CO., INC. (US) 2006-12-21 WO disclosed
CN-1289501-C Fused heterotricyclic compound, process for preparing compounds and drugs containing the same EISAI CO LTD (JP) 2006-12-13 CN disclosed
CN-1409713-A Tricyclic fused heterocyclic compound, process for producing the same, and pharmaceutical comprising the same EISAI CO LTD (JP) 2003-04-09 CN disclosed
CN-1237963-A Quinoline derivatives inhibiting the action of growth factors such as VEGF ZENECA LTD (GB) 1999-12-08 CN disclosed
EP-0929526-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1999-07-21 EP disclosed
WO-1998013350-A1 QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF ZENECA LIMITED (GB) 1998-04-02 WO disclosed
EP-0364254-A2 Decahydro-8H-isoquino[2,1-g][1,6]naphthyridine derivatives and related compounds SYNTEX (U.S.A.) INC. (US) 1990-04-18 EP disclosed