Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 9/20 | 0.35 |
| ▸ | TNKS | O95271 | 6/20 | 0.35 |
| ▸ | TACR3 | P29371 | 2/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | ERG | P11308 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1347704 | 0.85 | TNKS2 (0.38) | TNKS2TNKSTACR3AVPR1ATGFBR1 | |
| SCHEMBL1347781 | 0.85 | AVPR1A (0.44) | TNKS2TNKSTACR3AVPR1ATGFBR1 | |
| SCHEMBL3397440 | 0.83 | TNKS2 (0.43) | TNKS2TNKSTACR3AVPR1AERG | |
| SCHEMBL1347857 | 0.83 | TUBB4A (0.37) | TNKS2TNKSAVPR1ATGFBR1 | |
| SCHEMBL3399967 | 0.80 | AVPR1A (0.37) | HSD11B1TACR3AVPR1ATGFBR1MAP3K5 | |
| SCHEMBL3226167 | 0.72 | TNKS2 (0.37) | TNKS2TNKSTACR3ERGKCNH2 | |
| SCHEMBL1347208 | 0.71 | TNKS2 (0.36) | TNKS2TNKSTACR3 | |
| SCHEMBL1345591 | 0.70 | TNKS2 (0.35) | TNKS2TNKSTACR3TGFBR1ERG | |
| SCHEMBL12654553 | 0.69 | TNKS2 (0.39) | TNKS2TNKSTACR3TGFBR1ERG | |
| SCHEMBL12654555 | 0.68 | TNKS2 (0.37) | TNKS2TNKSTACR3AVPR1ATGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111403-B1 | TRIAZABENZO[E]AZULENE DERIVATIVES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2010-11-10 | — | — | EP | claimed |
| EP-2111403-B1 | TRIAZABENZO[E]AZULENE DERIVATIVES FOR THE TREATMENT OF TUMORS | MERCK PATENT GMBH (DE) | 2010-11-10 | — | — | EP | disclosed |