Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 8/20 | 0.53 |
| ▸ | SYK | P43405 | 3/20 | 0.39 |
| ▸ | TYRO3 | Q06418 | 7/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398063 | 0.85 | JAK3 (0.51) | JAK3SYKTYRO3 | |
| SCHEMBL2279625 | 0.83 | JAK3 (0.64) | JAK3SYKCYP2D6 | |
| SCHEMBL3395994 | 0.81 | JAK3 (0.37) | JAK3SYKTYRO3MAP4K4CYP2D6 | |
| SCHEMBL2275686 | 0.79 | JAK3 (0.58) | JAK3SYKCYP2D6 | |
| SCHEMBL2275335 | 0.76 | JAK3 (0.58) | JAK3SYKCYP2D6 | |
| SCHEMBL2281083 | 0.76 | JAK3 (0.56) | JAK3SYK | |
| SCHEMBL2280877 | 0.76 | JAK3 (0.61) | JAK3SYKCYP2D6 | |
| SCHEMBL2279333 | 0.76 | JAK3 (0.61) | JAK3SYKCYP2D6 | |
| SCHEMBL2275442 | 0.76 | JAK3 (0.53) | JAK3SYKMAP4K4CYP2D6 | |
| SCHEMBL2278825 | 0.76 | JAK3 (0.60) | JAK3SYKCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |