Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.51 |
| ▸ | TYRO3 | Q06418 | 10/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | ITK | Q08881 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395992 | 0.85 | JAK3 (0.53) | JAK3TYRO3SYK | |
| SCHEMBL3398068 | 0.81 | TYRO3 (0.38) | JAK3TYRO3SYKBTKITK | |
| SCHEMBL2279625 | 0.81 | JAK3 (0.64) | JAK3SYKBTKITK | |
| SCHEMBL2275686 | 0.78 | JAK3 (0.58) | JAK3SYK | |
| SCHEMBL2280913 | 0.76 | JAK3 (0.59) | JAK3TYRO3SYKBTKITK | |
| SCHEMBL2273575 | 0.76 | JAK3 (0.54) | JAK3SYK | |
| SCHEMBL2275335 | 0.76 | JAK3 (0.58) | JAK3SYK | |
| SCHEMBL2280877 | 0.75 | JAK3 (0.61) | JAK3SYKBTKITK | |
| SCHEMBL2279333 | 0.75 | JAK3 (0.61) | JAK3SYK | |
| SCHEMBL2341372 | 0.75 | JAK3 (0.57) | JAK3TYRO3SYKBTKITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |