Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.66 |
| ▸ | HSP90AB1 | P08238 | 14/20 | 0.66 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | YTHDC1 | Q96MU7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3392746 | 0.90 | HSP90AB1 (0.69) | HSP90AA1HSP90AB1 | |
| SCHEMBL3395258 | 0.80 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL3396083 | 0.76 | HSP90AA1 (0.71) | HSP90AA1HSP90AB1PDE5A | |
| SCHEMBL3394559 | 0.74 | HSP90AB1 (0.71) | HSP90AA1HSP90AB1 | |
| SCHEMBL3396299 | 0.73 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL3389641 | 0.72 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL3396045 | 0.72 | HSP90AB1 (1.00) | HSP90AA1HSP90AB1 | |
| SCHEMBL3393045 | 0.72 | HSP90AB1 (0.85) | HSP90AA1HSP90AB1 | |
| SCHEMBL3395476 | 0.71 | HSP90AB1 (0.80) | HSP90AA1HSP90AB1 | |
| SCHEMBL3395139 | 0.68 | HSP90AB1 (0.88) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2145888-A1 | Deazapurine derivatives as HSP90-Inhibitors | Conforma Therapeutics Corporation (US) | 2010-01-20 | — | — | EP | disclosed |