Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 5/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | ITK | Q08881 | 2/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | BCR | P11274 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3397744 | 0.85 | NPC1 (0.41) | JAK3MAPK1BTKITKDYRK1A | |
| SCHEMBL3398248 | 0.84 | MAPK1 (0.40) | JAK3MAPK1BTKITKCYP3A4 | |
| SCHEMBL3395994 | 0.81 | JAK3 (0.37) | JAK3MAPK1BTKITKSYK | |
| SCHEMBL3394454 | 0.80 | JAK3 (0.41) | JAK3MAPK1BTKITKCYP3A4 | |
| SCHEMBL3398068 | 0.80 | TYRO3 (0.38) | JAK3MAPK1BTKITKSYK | |
| SCHEMBL3396088 | 0.79 | JAK3 (0.42) | JAK3MAPK1BTKITKCYP3A4 | |
| SCHEMBL3396178 | 0.79 | BTK (0.41) | JAK3MAPK1BTKITKSYK | |
| SCHEMBL3394716 | 0.79 | CYP2D6 (0.35) | JAK3MAPK1BTKITKSYK | |
| SCHEMBL3396695 | 0.79 | PARP1 (0.39) | JAK3MAPK1BTKITKCYP3A4 | |
| SCHEMBL3399086 | 0.79 | JAK3 (0.36) | JAK3MAPK1BTKITKMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |