Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYRO3 | Q06418 | 12/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.31 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395994 | 0.86 | JAK3 (0.37) | TYRO3JAK3BTKITKMAPK1 | |
| SCHEMBL3398063 | 0.81 | JAK3 (0.51) | TYRO3JAK3BTKITKSYK | |
| SCHEMBL3396277 | 0.80 | JAK3 (0.39) | JAK3BTKITKMAPK1SYK | |
| SCHEMBL3397744 | 0.77 | NPC1 (0.41) | TYRO3JAK3BTKITKMAPK1 | |
| SCHEMBL3398248 | 0.76 | MAPK1 (0.40) | JAK3BTKITKMAPK1SYK | |
| SCHEMBL3395804 | 0.75 | MAP4K4 (0.40) | TYRO3JAK3BTKITKMAPK1 | |
| SCHEMBL3399453 | 0.75 | JAK3 (0.36) | JAK3BTKITKMAPK1 | |
| SCHEMBL3398737 | 0.75 | JAK3 (0.36) | JAK3BTKITKMAPK1SYK | |
| SCHEMBL3391915 | 0.75 | JAK3 (0.37) | JAK3BTKITKMAPK1SYK | |
| SCHEMBL3396178 | 0.75 | BTK (0.41) | TYRO3JAK3BTKITKMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |