Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 16/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399521 | 0.92 | BRD4 (0.46) | BRD4 | |
| SCHEMBL3398594 | 0.83 | MAPK1 (0.38) | MAPK1JAK3 | |
| SCHEMBL3396888 | 0.80 | MAPK1 (0.37) | MAPK1JAK3 | |
| SCHEMBL3393739 | 0.78 | MAPK1 (0.39) | MAPK1JAK3 | |
| SCHEMBL2276241 | 0.77 | JAK3 (0.54) | BRD4MAPK1MLYCDJAK3 | |
| SCHEMBL3397744 | 0.76 | NPC1 (0.41) | MAPK1JAK3 | |
| SCHEMBL3398248 | 0.75 | MAPK1 (0.40) | MAPK1JAK3 | |
| SCHEMBL3397717 | 0.75 | MAPK1 (0.41) | MAPK1JAK3 | |
| SCHEMBL3398640 | 0.72 | MAPK1 (0.32) | MAPK1JAK3 | |
| SCHEMBL3395594 | 0.72 | MAP4K1 (0.44) | MAPK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |