Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SCN4A | P35499 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401190 | 0.90 | MEN1 (0.54) | HSD17B10KDM4EALDH1A1SCN4AHPGD | |
| SCHEMBL3401687 | 0.88 | KDM4E (0.61) | HSD17B10KDM4EALDH1A1SCN4AHPGD | |
| SCHEMBL206309 | 0.83 | HSD17B10 (0.55) | HSD17B10KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL3434303 | 0.82 | NPSR1 (0.66) | HSD17B10KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL5121387 | 0.77 | KDM4E (0.67) | HSD17B10KDM4EKMT2AMEN1GAA | |
| SCHEMBL206204 | 0.77 | SMN1; SMN2 (0.62) | HSD17B10KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL206214 | 0.76 | KDM4E (0.49) | HSD17B10KDM4EALDH1A1HPGDNPSR1 | |
| SCHEMBL29333202 | 0.76 | KDM4E (0.67) | KDM4EALDH1A1HPGDKMT2AMEN1 | |
| SCHEMBL21653205 | 0.75 | SCN4A (0.57) | KDM4EALDH1A1SCN4AHPGDKMT2A | |
| SCHEMBL206203 | 0.75 | KDM4E (0.46) | HSD17B10KDM4EALDH1A1HPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |