Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.49 |
| ▸ | SCN4A | P35499 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 2/20 | 0.44 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396366 | 0.90 | HSD17B10 (0.56) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL3401687 | 0.89 | KDM4E (0.61) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL206214 | 0.83 | KDM4E (0.49) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL3434303 | 0.79 | NPSR1 (0.66) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL5121387 | 0.78 | KDM4E (0.67) | MEN1KMT2AKDM4EHSD17B10POLB | |
| SCHEMBL206204 | 0.77 | SMN1; SMN2 (0.62) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL206309 | 0.76 | HSD17B10 (0.55) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL206203 | 0.76 | KDM4E (0.46) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 | |
| SCHEMBL6616917 | 0.72 | S1PR5 (0.60) | KDM4EHSD17B10ALDH1A1HPGDNPSR1 | |
| SCHEMBL3401612 | 0.72 | KMT2A (0.47) | MEN1KMT2AKDM4EHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |