Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 6/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 2/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18255965 | 1.00 | MTNR1B (0.45) | MTNR1BMTNR1ABRAFRAF1MAPT | |
| SCHEMBL3396544 | 1.00 | MTNR1B (0.45) | MTNR1BMTNR1ABRAFRAF1MAPT | |
| SCHEMBL633747 | 0.77 | PIK3CD (0.45) | MTNR1BMTNR1ABRAFMAPTGRM1 | |
| SCHEMBL633748 | 0.77 | PIK3CD (0.45) | MTNR1BMTNR1ABRAFMAPTGRM1 | |
| SCHEMBL633927 | 0.77 | PIK3CD (0.45) | MTNR1BMTNR1ABRAFMAPTGRM1 | |
| SCHEMBL634124 | 0.77 | CYP1A2 (0.48) | MTNR1BMTNR1ABRAFRAF1MAPT | |
| SCHEMBL633222 | 0.77 | MTNR1B (0.47) | MTNR1BMTNR1AMAPTGRM1EGFR | |
| SCHEMBL11243697 | 0.73 | TDP1 (0.42) | LMNA | |
| SCHEMBL11243695 | 0.73 | TDP1 (0.42) | LMNA | |
| SCHEMBL11243701 | 0.73 | TDP1 (0.42) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9505750-B2 | 5-aminocyclylmethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2016-11-29 | — | — | US | disclosed |
| EP-2245028-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009077989-A1 | 5-AMINOCYCLYLMETHYL-OXAZOLIDIN-2-ONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-06-25 | — | — | WO | disclosed |