Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 14/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 14/20 | 0.38 |
| ▸ | TSPO | P30536 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3396542 | 0.87 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL3401901 | 0.79 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL2127140 | 0.77 | HCRTR1 (0.44) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3398589 | 0.77 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL3402866 | 0.77 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL2127144 | 0.76 | HCRTR1 (0.44) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL3400293 | 0.76 | HCRTR1 (0.41) | HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL3403072 | 0.74 | HCRTR1 (0.38) | HCRTR1HCRTR2 | |
| SCHEMBL3825411 | 0.69 | HCRTR1 (0.38) | HCRTR1HCRTR2TSPOOPRK1HTR2B | |
| SCHEMBL2127083 | 0.67 | HCRTR1 (0.44) | HCRTR1HCRTR2TSPOOPRK1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247586-A1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-10 | — | — | EP | claimed |
| WO-2009104155-A1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-08-27 | — | — | WO | claimed |
| EP-2247586-A1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009104155-A1 | 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-08-27 | — | — | WO | disclosed |