SCHEMBL3400293

SCHEMBL3400293

[CH2][C@H]1N(C(=O)c2nc(N(C)CC)sc2-c2cccc(OC)c2)[C@H]2CC[C@@]1(C(N)=O)C2

nearest known ligand 0.41

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HCRTR1 O43613 17/20 0.41
HCRTR2 O43614 16/20 0.41
NPC1 O15118 1/20 0.34
ALDH1A1 P00352 1/20 0.34
TP53 P04637 1/20 0.34
HPGD P15428 1/20 0.34
TSHR P16473 1/20 0.34
HTT P42858 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
BRAF P15056 1/20 0.34
PDE4A P27815 1/20 0.34
PDE4B Q07343 1/20 0.34
PDE4C Q08493 1/20 0.34
PDE4D Q08499 1/20 0.34
UCHL1 P09936 1/20 0.34
USP30 Q70CQ3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3401901 0.84 HCRTR1 (0.38) HCRTR1HCRTR2
SCHEMBL3403072 0.79 HCRTR1 (0.38) HCRTR1HCRTR2UCHL1
SCHEMBL2128526 0.79 HCRTR1 (0.41) HCRTR1HCRTR2NPC1ALDH1A1TP53
SCHEMBL2128535 0.78 HCRTR1 (0.39) HCRTR1HCRTR2NPC1ALDH1A1TP53
SCHEMBL3396542 0.77 HCRTR1 (0.38) HCRTR1HCRTR2
SCHEMBL3402866 0.76 HCRTR1 (0.38) HCRTR1HCRTR2
SCHEMBL3396570 0.76 HCRTR1 (0.38) HCRTR1HCRTR2NPC1RAB9ASMN1; SMN2
SCHEMBL3398589 0.76 HCRTR1 (0.38) HCRTR1HCRTR2PDE4APDE4BPDE4C
SCHEMBL3399565 0.75 HCRTR1 (0.36) HCRTR1HCRTR2
SCHEMBL2635383 0.75 HCRTR1 (0.46) HCRTR1HCRTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2247586-A1 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES Actelion Pharmaceuticals Ltd. (CH) 2010-11-10 EP claimed
WO-2009104155-A1 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2009-08-27 WO claimed
EP-2247586-A1 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES Actelion Pharmaceuticals Ltd. (CH) 2010-11-10 EP disclosed
WO-2009104155-A1 2-AZA-BICYCLO[2.2.1]HEPTANE DERIVATIVES ACTELION PHARMACEUTICALS LTD (CH) 2009-08-27 WO disclosed