Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1440004 | 0.81 | SMN1; SMN2 (0.41) | SMN1; SMN2S1PR5ALDH1A1 | |
| SCHEMBL23557645 | 0.81 | KMT2A (0.51) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL21047360 | 0.81 | KMT2A (0.51) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL12002343 | 0.80 | KMT2A (0.50) | SMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL1609328 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2S1PR5ALDH1A1 | |
| SCHEMBL740141 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2S1PR5ALDH1A1 | |
| SCHEMBL771607 | 0.79 | SMN1; SMN2 (0.54) | SMN1; SMN2S1PR5ALDH1A1 | |
| SCHEMBL6664351 | 0.77 | KDM4E (0.46) | SMN1; SMN2ALDH1A1 | |
| Hydrochloric Acid SCHEMBL19638092 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2S1PR5ALDH1A1 | |
| Hydrochloric Acid SCHEMBL613075 | 0.77 | SMN1; SMN2 (0.56) | SMN1; SMN2S1PR5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |
| WO-2009029375-A1 | NOVEL INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-03-05 | — | — | WO | disclosed |