Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15516138 | 1.00 | GAA (0.51) | GAAALDH1A1SMN1; SMN2CHRM1TDP1 | |
| SCHEMBL15520871 | 1.00 | GAA (0.51) | GAAALDH1A1SMN1; SMN2CHRM1TDP1 | |
| SCHEMBL3400414 | 0.89 | GAA (0.45) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL20385047 | 0.89 | GAA (0.45) | GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL4546658 | 0.86 | GAA (0.53) | GAAALDH1A1SMN1; SMN2CHRM1TDP1 | |
| SCHEMBL14009821 | 0.82 | MEN1 (0.44) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL14009822 | 0.82 | MEN1 (0.44) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4756275 | 0.82 | LMNA (0.49) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4754510 | 0.82 | LMNA (0.49) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4757581 | 0.82 | LMNA (0.49) | GAAALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |