Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.54 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.54 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2688840 | 0.93 | ALDH1A1 (0.60) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL5808629 | 0.91 | ALDH1A1 (0.59) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL2686071 | 0.89 | HPGD (0.75) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL17907473 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL4556914 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL2939314 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL8108012 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL2938836 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL1221883 | 0.87 | HPGD (0.79) | HPGDCHRNB2CHRNA3CHRNA4CHRNB3 | |
| SCHEMBL415383 | 0.86 | SMN1; SMN2 (0.50) | HPGDGAAALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2006130426-A2 | MODULATORS OF CCR-5 ACTIVITY | KEMIA, INC. (US) | 2006-12-07 | — | — | WO | disclosed |