Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400414 | 0.90 | GAA (0.45) | ALDH1A1MAPK1LMNAGAA | |
| SCHEMBL20385047 | 0.90 | GAA (0.45) | ALDH1A1MAPK1LMNAGAA | |
| SCHEMBL10311690 | 0.88 | ALDH1A1 (0.55) | ALDH1A1MAPK1LMNAHSD17B10GLA | |
| SCHEMBL20839141 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPK1HSD17B10KMT2ARAB9A | |
| SCHEMBL20839142 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPK1HSD17B10KMT2ARAB9A | |
| SCHEMBL13688865 | 0.83 | ALDH1A1 (0.50) | ALDH1A1MAPK1LMNAHSD17B10GLA | |
| SCHEMBL12884802 | 0.80 | ALDH1A1 (0.50) | ALDH1A1MAPK1LMNAHSD17B10GLA | |
| SCHEMBL3400585 | 0.79 | TLR9 (0.37) | ALDH1A1KMT2A | |
| SCHEMBL3399856 | 0.79 | TLR9 (0.37) | ALDH1A1KMT2A | |
| SCHEMBL3398264 | 0.79 | ALDH1A1 (0.59) | ALDH1A1MAPK1LMNAHSD17B10GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |