Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLCG1 | P19174 | 1/20 | 0.63 |
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.61 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.51 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.47 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.47 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.47 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.47 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9463349 | 1.00 | PLCG1 (0.63) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL5706045 | 1.00 | PLCG1 (0.63) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL9463353 | 1.00 | PLCG1 (0.63) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL15500602 | 1.00 | PLCG1 (0.63) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL3397247 | 1.00 | PLCG1 (0.63) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL11038535 | 0.93 | TDP1 (0.66) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL11319192 | 0.93 | TDP1 (0.66) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL11319197 | 0.93 | TDP1 (0.66) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL11038537 | 0.93 | TDP1 (0.66) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 | |
| SCHEMBL13102118 | 0.92 | PLCG1 (0.64) | PLCG1TDP1CTDSP1L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10239890-B2 | Broad spectrum beta-lactamase inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2019-03-26 | — | — | US | disclosed |
| US-20180273549-A1 | Broad Spectrum Beta-Lactamase Inhibitors | SOPHARMIA, INC. | 2018-09-27 | — | — | US | disclosed |
| US-10000509-B2 | Broad spectrum beta-lactamase inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2018-06-19 | — | — | US | disclosed |
| US-20180065989-A1 | Broad Spectrum Beta-Lactamase Inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2018-03-08 | — | — | US | disclosed |
| US-9862729-B2 | Broad spectrum beta-lactamase inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2018-01-09 | — | — | US | disclosed |
| US-20170327515-A1 | Broad Spectrum Beta-Lactamase Inhibitors | SOPHARMIA, INC. | 2017-11-16 | — | — | US | disclosed |
| US-9809605-B1 | Broad spectrum beta-lactamase inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2017-11-07 | — | — | US | disclosed |
| US-20160362422-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2016-12-15 | — | — | US | disclosed |
| US-9453032-B2 | Broad spectrum beta-lactamase inhibitors | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2016-09-27 | — | — | US | disclosed |
| US-20150011524-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | SOPHARMIA, INC. | 2015-01-08 | — | — | US | disclosed |
| US-8883772-B2 | Broad spectrum beta-lactamase inhibitors | SOPHARMIA, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-20100261700-A1 | BETA-LACTAMASE INHIBITORS | SOPHARMIA, INC. | 2010-10-14 | — | — | US | disclosed |
| US-20090131394-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | GLADIUS PHARMACEUTICALS CORPORATION (CA) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180065989-A1 | Broad Spectrum Beta-Lactamase Inhibitors | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20170327515-A1 | Broad Spectrum Beta-Lactamase Inhibitors | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20180273549-A1 | Broad Spectrum Beta-Lactamase Inhibitors | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20090131394-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20160362422-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20100261700-A1 | BETA-LACTAMASE INHIBITORS | PEPD, LCT, GAA | PLCG1 1704/4885TDP1 2148/4885CTDSP1 2093/4885 |
| US-10239890-B2 | Broad spectrum beta-lactamase inhibitors | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-20150011524-A1 | BROAD SPECTRUM BETA-LACTAMASE INHIBITORS | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
| US-10000509-B2 | Broad spectrum beta-lactamase inhibitors | PEPD, MGAM, NAALAD2 | PLCG1 2357/4885TDP1 2266/4885CTDSP1 1895/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.