Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 9/20 | 0.42 |
| ▸ | CSNK1E | P49674 | 9/20 | 0.42 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954869 | 0.90 | KDR (0.48) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL251983 | 0.89 | KDR (0.43) | KDRCSNK1DCSNK1EMET | |
| SCHEMBL250805 | 0.89 | KDR (0.43) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5955351 | 0.89 | KDR (0.43) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL252254 | 0.89 | KDR (0.43) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL6006706 | 0.89 | KDR (0.44) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL252980 | 0.88 | KDR (0.43) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5954382 | 0.87 | KDR (0.42) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5955024 | 0.87 | KDR (0.44) | KDRCSNK1DCSNK1EMET | |
| SCHEMBL5954136 | 0.87 | KDR (0.42) | KDRCSNK1DCSNK1EMETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012003338-A1 | COMBINATION OF A cMET INHIBITOR AND AN ANTIBODY TO HGF AND/OR cMET | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-01-05 | — | — | WO | disclosed |
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |