Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.44 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.41 |
| ▸ | CSNK1E | P49674 | 5/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.37 |
| ▸ | FLT1 | P17948 | 2/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.37 |
| ▸ | YES1 | P07947 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | BCR | P11274 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT4 | P35916 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.37 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5954398 | 0.89 | KDR (0.46) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5954391 | 0.89 | KDR (0.44) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL252682 | 0.89 | KDR (0.46) | KDRCSNK1DCSNK1EMETPDGFRB | |
| SCHEMBL5954421 | 0.89 | KDR (0.44) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL3397327 | 0.89 | KDR (0.44) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5955071 | 0.87 | KDR (0.44) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5955371 | 0.86 | KDR (0.46) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL251711 | 0.86 | CSNK1D (0.53) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL5954869 | 0.83 | KDR (0.48) | KDRCSNK1DCSNK1EMETBRAF | |
| SCHEMBL252254 | 0.82 | KDR (0.43) | KDRCSNK1DCSNK1EMETBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010019899-A1 | cMET INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-02-18 | — | — | WO | disclosed |