Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | PADI1 | Q9ULC6 | 1/20 | 0.33 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAD52 | P43351 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20407544 | 0.84 | — | — | |
| SCHEMBL8902458 | 0.80 | HSD17B10 (0.44) | SMN1; SMN2CHRM3ANPEPERAP2POLB | |
| SCHEMBL9431693 | 0.78 | HSD17B10 (0.47) | SMN1; SMN2CHRM3ANPEPERAP2SIGMAR1 | |
| SCHEMBL1372330 | 0.76 | SMN1; SMN2 (0.47) | SMN1; SMN2CHRM5CHRM3PADI1PADI4 | |
| SCHEMBL24444712 | 0.75 | PIK3CD (0.34) | PIK3CD | |
| SCHEMBL16464438 | 0.75 | SMN1; SMN2 (0.43) | SMN1; SMN2CHRM5CHRM3PADI1PADI4 | |
| SCHEMBL7812231 | 0.75 | ALDH1A1 (0.52) | SMN1; SMN2ANPEPLMNAMEN1ALDH1A1 | |
| SCHEMBL6921848 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM5CHRM3PADI1PADI4 | |
| SCHEMBL208440 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2CHRM5CHRM3PADI1PADI4 | |
| SCHEMBL27632715 | 0.75 | SMN1; SMN2 (0.44) | SMN1; SMN2CHRM5CHRM3PADI1PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021055744-A1 | 4-SUBSTITUTED INDOLE AND INDAZOLE SULFONAMIDO DERIVATIVES AS PARG INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2021-03-25 | — | — | WO | disclosed |
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |