Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.81 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.64 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.57 |
| ▸ | DRD1 | P21728 | 1/20 | 0.56 |
| ▸ | DRD4 | P21917 | 1/20 | 0.56 |
| ▸ | DRD5 | P21918 | 1/20 | 0.56 |
| ▸ | DRD3 | P35462 | 1/20 | 0.56 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.56 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399715 | 0.90 | DRD2 (1.00) | DRD2SLC6A4SLC18A3DRD1DRD4 | |
| SCHEMBL12319791 | 0.87 | DRD2 (0.60) | DRD2SLC6A4SLC18A3DRD3CARM1 | |
| Hydrochloric Acid SCHEMBL3331807 | 0.83 | DRD2 (0.84) | DRD2SLC6A4SLC18A3DRD1DRD4 | |
| SCHEMBL1546830 | 0.81 | DRD2 (0.83) | DRD2SLC6A4SLC18A3DRD1DRD4 | |
| SCHEMBL8351025 | 0.81 | DRD2 (0.75) | DRD2SLC6A4SIGMAR1 | |
| SCHEMBL1546828 | 0.81 | DRD2 (0.83) | DRD2SLC6A4SLC18A3DRD1DRD4 | |
| SCHEMBL12902348 | 0.81 | DRD2 (0.51) | DRD2SLC18A3CARM1PRMT6 | |
| SCHEMBL8207578 | 0.80 | DRD2 (0.73) | DRD2SLC6A4DRD1DRD5DRD3 | |
| SCHEMBL152587 | 0.80 | DRD2 (0.81) | DRD2SLC18A3DRD1DRD4DRD5 | |
| SCHEMBL31223124 | 0.80 | DRD2 (0.73) | DRD2SLC6A4SLC18A3DRD1DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2247600-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | Lead Therapeutics, Inc. (US) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009099736-A2 | BENZOXAZOLE CARBOXAMIDE INHIBITORS OF POLY(ADP-RIBOSE)POLYMERASE (PARP) | LEAD THERAPEUTICS, INC. (US) | 2009-08-13 | — | — | WO | disclosed |