Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 4/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | CTSB | P07858 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | CTSS | P25774 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3394965 | 0.84 | DPP4 (0.47) | GRIN2BHSD11B1CTSLCTSBCTSK | |
| SCHEMBL13001043 | 0.84 | DPP4 (0.47) | GRIN2BHSD11B1CTSLCTSBCTSK | |
| SCHEMBL20556133 | 0.79 | GRIN2B (0.53) | GRIN2BGRM2HSD11B1 | |
| SCHEMBL1818822 | 0.74 | HSD11B1 (0.39) | HSD11B1 | |
| SCHEMBL3110888 | 0.71 | HSD11B1 (0.33) | HSD11B1 | |
| SCHEMBL8512675 | 0.70 | GRIN2B (0.33) | GRIN2B | |
| SCHEMBL8512673 | 0.70 | GRIN2B (0.33) | GRIN2B | |
| SCHEMBL8512668 | 0.70 | GRIN2B (0.33) | GRIN2B | |
| SCHEMBL8511685 | 0.68 | GRIN2B (0.30) | GRIN2B | |
| SCHEMBL20788762 | 0.68 | DPP4 (0.34) | GRIN2BDPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246347-B1 | DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF | SHANGHAI HENGRUI PHARM CO LTD (CN) | 2016-09-28 | — | — | EP | disclosed |
| EP-2246347-A1 | DICYCLOAZAALKANE DERIVATES, PREPARATION PROCESSES AND MEDICAL USES THEREOF | Shanghai Hengrui Pharmaceutical Co. Ltd. (CN) | 2010-11-03 | — | — | EP | disclosed |