Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.51 |
| ▸ | CA9 | Q16790 | 3/20 | 0.51 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5716839 | 0.90 | CA12 (0.55) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3402325 | 0.82 | CA12 (0.56) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3403806 | 0.80 | CA12 (0.50) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL7061811 | 0.77 | HTR6 (0.48) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL1177272 | 0.77 | CA12 (0.58) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3433282 | 0.75 | CA12 (0.60) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL3558164 | 0.74 | CA12 (0.78) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL7066129 | 0.74 | BCL2 (0.48) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL30276218 | 0.73 | CA12 (0.52) | CA12CA9CA2CREBBPRECQL | |
| SCHEMBL369194 | 0.73 | CA12 (0.52) | CA12CA9CA2CREBBPRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2222659-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | The Ohio State University Research Foundation (US) | 2010-09-01 | — | — | EP | disclosed |
| WO-2009070645-A1 | INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF | THE OHIO UNIVERSITY RESEARCH FOUNDATION (US) | 2009-06-04 | — | — | WO | disclosed |