Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 4/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.53 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.43 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29432635 | 1.00 | DYRK1A (0.54) | DYRK1AMKNK1MKNK2MAP4K4AAK1 | |
| SCHEMBL30337203 | 0.84 | DYRK1A (0.70) | DYRK1AMKNK1MKNK2AAK1PDPK1 | |
| SCHEMBL18998664 | 0.82 | CLK4 (0.59) | DYRK1AMAP4K4CDC7CDK2GSK3B | |
| SCHEMBL30935767 | 0.79 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2AAK1PDPK1 | |
| SCHEMBL4402187 | 0.79 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2AAK1PDPK1 | |
| SCHEMBL23809629 | 0.79 | MYC (0.57) | DYRK1AMKNK1MKNK2AAK1PDPK1 | |
| SCHEMBL23809618 | 0.79 | DYRK1A (0.45) | DYRK1AMKNK1MKNK2AAK1CDC7 | |
| SCHEMBL15649966 | 0.78 | DYRK1A (0.63) | DYRK1AMKNK1MKNK2AAK1PDPK1 | |
| SCHEMBL31294130 | 0.78 | — | — | |
| SCHEMBL312451 | 0.78 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2025-05-06 | — | — | US | disclosed |
| EP-3966204-B1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO LTD (CN) | 2024-11-27 | — | — | EP | disclosed |
| CN-111909133-B | Substituted 1-amino-1H-imidazole-5-carboxamides as inhibitors of brunauer tyrosine kinase | 河南知微生物医药有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2022-08-18 | — | — | US | disclosed |
| WO-2020228637-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN NORMAL UNIVERSITY (CN) | 2020-11-19 | — | — | WO | disclosed |
| CN-111909133-A | Substituted 1-amino-1H-imidazole-5-carboxamides as brunauer tyrosine kinase inhibitors | 河南师范大学 | 2020-11-10 | — | — | CN | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010046780-A2 | ANTI VIRAL COMPOUNDS | INSTITUT PASTEUR KOREA (KR) | 2010-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | BTK, SYK, TYK2 | DYRK1A 114/4885MKNK1 674/4885MKNK2 767/4885 |
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | BTK, SYK, TYK2 | DYRK1A 114/4885MKNK1 674/4885MKNK2 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.