Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 3/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2248064 | 0.88 | TMEM97 (0.38) | CHRM4CHRM2CHRM1CHRM3 | |
| SCHEMBL12356488 | 0.88 | TMEM97 (0.38) | CHRM4CHRM2CHRM1CHRM3 | |
| SCHEMBL12367369 | 0.88 | TMEM97 (0.38) | CHRM4CHRM2CHRM1CHRM3 | |
| SCHEMBL2246278 | 0.81 | MAPT (0.31) | MAPTHSP90AB1 | |
| SCHEMBL2245181 | 0.80 | GPR119 (0.40) | GPR119MAPTLMNATP53 | |
| SCHEMBL2245448 | 0.80 | GPR119 (0.40) | GPR119MAPTLMNATP53 | |
| SCHEMBL12356460 | 0.79 | GPR119 (0.42) | GPR119MAPTHCRTR2 | |
| SCHEMBL2248384 | 0.79 | GRIN2B (0.42) | CHRM4 | |
| SCHEMBL2247536 | 0.79 | MAPT (0.31) | MAPT | |
| SCHEMBL3403746 | 0.78 | MAPT (0.35) | GPR119MAPTHSP90AB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | claimed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | claimed |
| EP-2252613-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM, LLC (BM) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009105717-A1 | COMPOUNDS AND COMPOSITIONS AS MODULATORS OF GPR119 ACTIVITY | IRM LLC (BM) | 2009-08-27 | — | — | WO | disclosed |