Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 2/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 7/20 | 0.48 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | KIT | P10721 | 4/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3395228 | 0.90 | SYK (0.58) | SYKCYP2C9KITMAP3K11 | |
| SCHEMBL3399171 | 0.82 | SYK (0.61) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL3399365 | 0.81 | SYK (0.60) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL2278062 | 0.79 | SYK (0.66) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL2277395 | 0.78 | SYK (0.65) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL2282760 | 0.77 | SYK (0.69) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL2276549 | 0.77 | SYK (0.69) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL2279702 | 0.77 | SYK (0.69) | SYKCYP2C9 | |
| SCHEMBL2348404 | 0.76 | SYK (0.55) | SYKAAK1MAP4K1CYP2C9KIT | |
| SCHEMBL3396602 | 0.76 | PRKCI (0.39) | SYKMAP4K1KITMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |