Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 8/20 | 0.46 |
| ▸ | GPR6 | P46095 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.42 |
| ▸ | CKS1B | P61024 | 1/20 | 0.39 |
| ▸ | SKP1 | P63208 | 1/20 | 0.39 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2078247 | 0.89 | KMT2A (0.51) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084536 | 0.89 | CKS1B (0.49) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2085157 | 0.87 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084921 | 0.87 | ALDH1A1 (0.52) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084276 | 0.86 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2083337 | 0.86 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL14469016 | 0.85 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2082643 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2082799 | 0.85 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPTGS2 | |
| SCHEMBL2084529 | 0.83 | SLC2A1 (0.48) | PDE4APDE4BPDE4CPDE4DPTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101965338-A | Novel heterocycles | ORCHID RES LAB LTD | 2011-02-02 | — | — | CN | claimed |
| EP-2245017-A2 | NOVEL HETEROCYCLES | Orchid Research Laboratories Limited (IN) | 2010-11-03 | — | — | EP | claimed |
| WO-2009095773-A2 | NOVEL HETEROCYCLES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-08-06 | — | — | WO | claimed |
| EP-2245017-A2 | NOVEL HETEROCYCLES | Orchid Research Laboratories Limited (IN) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009095773-A2 | NOVEL HETEROCYCLES | ORCHID RESEARCH LABORATORIES LIMITED (IN) | 2009-08-06 | — | — | WO | disclosed |