Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.48 |
| ▸ | THRA | P10827 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3398373 | 0.93 | CNR1 (0.49) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3406022 | 0.92 | CNR1 (0.48) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3405916 | 0.90 | CNR1 (0.51) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3405774 | 0.90 | CNR1 (0.47) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3402351 | 0.88 | CNR1 (0.45) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3399579 | 0.88 | CNR1 (0.47) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3404377 | 0.87 | TRPM8 (0.57) | CNR1HTR2CTRPM8 | |
| SCHEMBL3406010 | 0.87 | CNR1 (0.49) | CNR1THRATHRBHTR2CGSK3B | |
| SCHEMBL3399685 | 0.87 | CNR1 (0.55) | CNR1THRATHRBHTR2CTRPM8 | |
| SCHEMBL3405399 | 0.84 | CNR1 (0.57) | CNR1THRATHRBHTR2CMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| US-7728009-B1 | Thiazole amides, imidazole amides and related analogues | NEUROGEN CORPORATION (US) | 2010-06-01 | — | — | US | disclosed |
| WO-2006089076-A9 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORP (US) | 2007-04-26 | — | — | WO | disclosed |