Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 6/20 | 0.37 |
| ▸ | WDR77 | Q9BQA1 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16624019 | 0.81 | ACACB (0.52) | ACACBNOTUMPHGDHPRMT5WDR77 | |
| SCHEMBL29964619 | 0.81 | ACACB (0.49) | ACACBNOTUMPHGDHPRMT5WDR77 | |
| SCHEMBL12450090 | 0.78 | CARM1 (0.51) | ACACBMAOBPRMT5WDR77JAK2 | |
| SCHEMBL21267646 | 0.78 | JAK2 (0.43) | MAOBPRMT5JAK2FLT3DRD2 | |
| SCHEMBL27749066 | 0.77 | ACACB (0.49) | ACACBNOTUMPHGDHPRMT5WDR77 | |
| SCHEMBL4390014 | 0.76 | ACACB (0.51) | ACACBPHGDHDRD2DRD3 | |
| SCHEMBL7962844 | 0.75 | ACACB (0.45) | ACACBDRD2DRD3 | |
| SCHEMBL30443592 | 0.75 | KDM4E (0.49) | MAOBMAOADRD2DRD3 | |
| SCHEMBL3450752 | 0.75 | KDM4E (0.49) | MAOBMAOADRD2DRD3 | |
| SCHEMBL6369620 | 0.75 | HRH3 (0.47) | ACACBNOTUMPRMT5WDR77DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2246329-A1 | 4(1H)-pyridinone derivatives and their use as antimalaria agents | Glaxo Group Limited (GB) | 2010-11-03 | — | — | EP | disclosed |