Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR7 | P34969 | 6/20 | 0.43 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6980960 | 0.95 | DRD3 (0.43) | ACACBDRD3DRD2HTR7HTR1A | |
| SCHEMBL4390014 | 0.85 | ACACB (0.51) | ACACBDRD3DRD2HTR7HTR1A | |
| SCHEMBL7973100 | 0.81 | ACACB (0.48) | ACACBDRD3DRD2HTR7HTR1A | |
| SCHEMBL4382326 | 0.80 | ACACB (0.46) | ACACBDRD3DRD2HTR7HTR1A | |
| SCHEMBL7979148 | 0.79 | CARM1 (0.49) | ACACBDRD3DRD2HTR7SLC6A4 | |
| SCHEMBL16624019 | 0.79 | ACACB (0.52) | ACACBDRD3DRD2PNMT | |
| SCHEMBL29964619 | 0.79 | ACACB (0.49) | ACACBDRD3DRD2 | |
| SCHEMBL7979139 | 0.78 | DRD3 (0.49) | ACACBDRD3DRD2 | |
| SCHEMBL7634391 | 0.77 | ACACB (0.42) | ACACBDRD3DRD2SLC6A4 | |
| SCHEMBL8151957 | 0.77 | DRD2 (0.46) | ACACBDRD3DRD2HTR7HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6274593-B1 | TREATING PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA, AND PARKINSON*S DISEASE | SMITHKLINE BEECHAM P.L.C. (GB) | 2001-08-14 | — | — | US | disclosed |
| EP-0980357-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 2000-02-23 | — | — | EP | disclosed |
| WO-1998050363-A1 | SUBSTITUTED TETRAHYDRO ISOQUINOLINES AS MODULATORS OF DOPAMINE D3 RECEPTORS | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |