Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.41 |
| ▸ | CTSD | P07339 | 5/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2279077 | 0.88 | BACE1 (0.49) | BACE1CTSDTAAR1NPY5R | |
| SCHEMBL2279462 | 0.88 | BACE1 (0.49) | BACE1CTSDTAAR1NPY5R | |
| SCHEMBL3399127 | 0.87 | BACE1 (0.54) | BACE1CTSDTAAR1 | |
| SCHEMBL3398692 | 0.85 | BACE1 (0.46) | BACE1CTSDTAAR1 | |
| SCHEMBL3399266 | 0.83 | BACE1 (0.39) | BACE1CTSDTAAR1CTSLMEN1 | |
| SCHEMBL3393576 | 0.83 | BACE1 (0.44) | BACE1CTSDTAAR1 | |
| SCHEMBL3427565 | 0.82 | BACE1 (0.43) | BACE1CTSDTAAR1 | |
| SCHEMBL3399227 | 0.81 | BACE1 (0.36) | BACE1CTSDTAAR1 | |
| SCHEMBL3393923 | 0.81 | BACE1 (0.47) | BACE1CTSDTAAR1MEN1GAA | |
| SCHEMBL3398471 | 0.80 | BACE1 (0.43) | BACE1CTSDTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |