Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 11/20 | 0.39 |
| ▸ | CTSD | P07339 | 6/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.36 |
| ▸ | CHRNG | P07510 | 2/20 | 0.36 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRND | Q07001 | 2/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2276540 | 0.89 | BACE1 (0.46) | BACE1CTSDTAAR1CHRNA1CHRNG | |
| SCHEMBL2276542 | 0.89 | BACE1 (0.46) | BACE1CTSDTAAR1CHRNA1CHRNG | |
| SCHEMBL3398703 | 0.83 | BACE1 (0.41) | BACE1CTSDTAAR1CTSLMEN1 | |
| SCHEMBL3398692 | 0.81 | BACE1 (0.46) | BACE1CTSDTAAR1 | |
| SCHEMBL3393923 | 0.80 | BACE1 (0.47) | BACE1CTSDTAAR1MEN1GAA | |
| SCHEMBL3393576 | 0.79 | BACE1 (0.44) | BACE1CTSDTAAR1 | |
| SCHEMBL3399127 | 0.79 | BACE1 (0.54) | BACE1CTSDTAAR1 | |
| SCHEMBL2285631 | 0.78 | BACE1 (0.49) | BACE1CTSDTAAR1 | |
| SCHEMBL2285635 | 0.78 | BACE1 (0.49) | BACE1CTSDTAAR1 | |
| SCHEMBL3399227 | 0.77 | BACE1 (0.36) | BACE1CTSDTAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245019-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| WO-2009103626-A1 | 4, 5-DIHYDRO-OXAZOL-2-YL AMINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-08-27 | — | — | WO | disclosed |