Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKACA | P17612 | 3/20 | 0.45 |
| ▸ | PRKACG | P22612 | 3/20 | 0.45 |
| ▸ | PRKACB | P22694 | 3/20 | 0.45 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 3/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.34 |
| ▸ | CNR2 | P34972 | 5/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.33 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3399506 | 0.90 | HTR2C (0.40) | JAK3CNR2JAK2 | |
| SCHEMBL3395585 | 0.88 | CCR3 (0.36) | JAK3 | |
| SCHEMBL3399527 | 0.87 | CNR2 (0.38) | JAK3CNR2CNR1TNIK | |
| SCHEMBL3398118 | 0.87 | MAP4K4 (0.39) | JAK3EGFRERBB2CNR2CNR1 | |
| SCHEMBL3391981 | 0.87 | JAK3 (0.36) | JAK3CNR2CNR1JAK2JAK1 | |
| SCHEMBL3396467 | 0.87 | CNR2 (0.39) | JAK3CNR2CNR1 | |
| SCHEMBL3399133 | 0.86 | TNIK (0.43) | TNIK | |
| SCHEMBL3395505 | 0.85 | JAK3 (0.35) | JAK3CNR2CNR1JAK2TNIK | |
| SCHEMBL3395609 | 0.83 | PRKCA (0.41) | JAK3PIM1JAK2 | |
| SCHEMBL3395555 | 0.83 | JAK3 (0.37) | JAK3PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | claimed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | claimed |