Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2342156 | 0.78 | SYK (0.46) | SYKJAK3 | |
| SCHEMBL3396108 | 0.77 | — | — | |
| SCHEMBL3395483 | 0.77 | MAPK1 (0.47) | — | |
| SCHEMBL3399031 | 0.76 | ALOX5AP (0.36) | SYK | |
| SCHEMBL2343779 | 0.75 | MAPK1 (0.36) | SYKJAK3 | |
| SCHEMBL3400025 | 0.74 | JAK3 (0.32) | JAK3 | |
| SCHEMBL3394454 | 0.74 | JAK3 (0.41) | SYKJAK3 | |
| SCHEMBL3396844 | 0.73 | NOS1 (0.40) | SYK | |
| SCHEMBL3397744 | 0.73 | NPC1 (0.41) | SYKJAK3 | |
| SCHEMBL2338768 | 0.73 | JAK3 (0.64) | SYKJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2250172-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-17 | — | — | EP | disclosed |
| WO-2009106443-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |