SCHEMBL3399237

SCHEMBL3399237

Nc1nncc(-c2ccc(-c3ccccc3)cc2)n1

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA2A P29274 4/20 0.68
ADORA1 P30542 3/20 0.68
GABRA1 P14867 2/20 0.50
GABRG2 P18507 2/20 0.50
GABRB3 P28472 2/20 0.50
GABRA5 P31644 2/20 0.50
GABRA3 P34903 2/20 0.50
HSP90AA1 P07900 2/20 0.48
AURKA O14965 1/20 0.48
PRKACA P17612 1/20 0.48
CYP1A1 P04798 1/20 0.47
CYP1B1 Q16678 1/20 0.47
ALDH1A1 P00352 5/20 0.47
NPC1 O15118 4/20 0.47
RAB9A P51151 3/20 0.47
KDM4E B2RXH2 3/20 0.47
MAPT P10636 3/20 0.47
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
LMNA P02545 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2325695 0.96 ADORA2A (0.67) ADORA2AADORA1GABRA1GABRG2GABRB3
SCHEMBL31009002 0.96 ADORA2A (0.67) ADORA2AADORA1GABRA1GABRG2GABRB3
SCHEMBL3395696 0.87 ADORA2A (0.53) ADORA2AADORA1GABRA1GABRG2GABRB3
SCHEMBL3395736 0.81 ADORA2A (0.50) ADORA2AADORA1GABRA1GABRG2GABRB3
SCHEMBL29914245 0.81 ADORA1 (0.68) ADORA2AADORA1GABRG2GABRB3GABRA5
SCHEMBL2322815 0.81 ADORA2A (0.68) ADORA2AADORA1ALDH1A1NPC1RAB9A
SCHEMBL3398538 0.81 ADORA2A (1.00) ADORA2AADORA1ALDH1A1NPC1RAB9A
SCHEMBL3530116 0.81 ADORA2A (0.68) ADORA2AADORA1ALDH1A1NPC1RAB9A
SCHEMBL2326019 0.81 ADORA1 (0.68) ADORA2AADORA1GABRG2GABRB3GABRA5
SCHEMBL2322824 0.81 ADORA2A (0.68) ADORA2AADORA1ALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed
WO-2010046780-A2 ANTI VIRAL COMPOUNDS INSTITUT PASTEUR KOREA (KR) 2010-04-29 WO disclosed