Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMYD3 | Q9H7B4 | 12/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3210529 | 1.00 | POLB (0.57) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| SCHEMBL3210521 | 1.00 | POLB (0.57) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| SCHEMBL21490070 | 1.00 | POLB (0.57) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| SCHEMBL8235358 | 1.00 | POLB (0.57) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| SCHEMBL19701343 | 1.00 | POLB (0.57) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL987518 | 0.98 | POLB (0.55) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| Hydrochloric Acid SCHEMBL987519 | 0.98 | POLB (0.55) | POLBSMYD3L3MBTL1HSD17B10MAPK1 | |
| SCHEMBL3808039 | 0.90 | L3MBTL1 (0.50) | POLBSMYD3L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL12101939 | 0.90 | POLB (0.52) | POLBSMYD3L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL19739542 | 0.90 | POLB (0.52) | POLBSMYD3L3MBTL1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | claimed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | claimed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | claimed |
| US-8445501-B2 | Substituted 7-carboxamido-pyrrolo[3,2-d]pyrimidines | TAKEDA GMBH (DE) | 2013-05-21 | — | — | US | disclosed |
| EP-2247594-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | Nycomed GmbH (DE) | 2010-11-10 | — | — | EP | disclosed |
| WO-2009106531-A1 | PYRROLOPYRIMIDINECARBOXAMIDES | NYCOMED GMBH (DE) | 2009-09-03 | — | — | WO | disclosed |
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |